CNSC-04. EVALUATING LONGITUDINAL WORKING MEMORY PERFORMANCE IN PEDIATRIC PATIENTS WITH CRANIOPHARYNGIOMA VIA FMRI

Abstract Craniopharyngioma is a type of benign brain tumor that develops in the suprasellar region and can lead to long-term neurological, endocrine, visual impairments as well neurocognitive deficits resulting from its treatment. The contemporary treatment options for this are radical surgery or limited conjunction with radiotherapy. current understanding impact injury related such proton radiotherapy (PRT) on function limited. study (NCT01419067) was approved by IRB informed consent obtained patients their parents. Functional magnetic resonance imaging (fMRI) performed 3T MRI system (Siemens MAGNETOM Prisma, Erlangen, Germany) used evaluate performance 58 pediatric (31 females 27 males) before after (PRT). underwent serial at four-time points (baseline, 18, 36, 60 months PRT) working memory (0-back, 1-back, 2-back) task-based fMRI. A full factorial model longitudinal group analysis different time through statistical parametric mapping. Omission errors, commission reaction were measured each task. results showed robust detection network increased activation (FDR<0.05) precuneus, mid-temporal gyrus, angular gyrus 36 compared 18 months. behavioral test gradual decrease omission errors 2-back task an increase all three groups over time. These findings suggest PRT has transient effect performance, potentially indicating improved executive functioning, recovery mass and/or surgery, minimal negative PRT.